When can patients expect introduction of Prostvac as a treatment option for localized Adenocarcinoma?

P Ca patients with localised lesions with low to intermediate risk are faced with the side effects of radical therapies. There is news of an ongoing trial of Prostvac as immunotherapy for localised P Ca to halt disease progression. Is it possible to share the current status please? Thanks.


Community Answers
  • Richard Faust moderator
    5 months ago

    Thanks so much for sharing this information PeeKaaFighter. I noticed the expected completion date for the trial is now less than a year out. Hopefully this one will offer some positive results. I didn’t find any additional information on it, which isn’t surprising considering there is almost never news released while the study is ongoing (unless it is halted for some reason – so, no news is good news on that front). Best, Richard (ProstateCancer.net Team)

  • PeeKaaFighter author
    5 months ago

    Hi,

    Apropos my previous post on news of trial of Provenge for checking disease progression in patients with early stage P Ca, I could get this link which may be of interest https://twitter.com/DendreonNews/status/997507247180726272

  • ninaw moderator
    5 months ago

    Thanks for sharing this update, @PeeKaaFighter. – Nina, ProstateCancer.net Team

  • Richard Faust moderator
    6 months ago

    Hi PeeKaaFighter.Glad to see you are doing research into treatments. Unfortunately, a Phase III trial for PROSTVAC was discontinued last fall after performing no better than a placebo. Here is the company’s statement on the discontinuation: http://www.bavarian-nordic.com/pipeline/prostvac.aspx. The statement mentions potentially pursuing other possible uses for the drug, including combination therapies, however, I did not find anything about this research (this certainly does not mean it doesn’t exist). Best, Richard (ProstateCancer.net Team)

  • PeeKaaFighter author
    5 months ago

    Hi,

    Thank you for the response.

    I did come to hear of the Prostvac phase III trial discontinuation. That trial was for metastatic prostate cancer.

    But there was mention of a trial on efficacy of Prostvac in relation to localized prostate cancer with the aim to halt disease progression. Here is a link https://clinicaltrials.gov/ct2/show/NCT02326805

    Similarly, there was mention in 2012 of possibility of trying Provenge treatment at an early stage of the disease. But nothing has been heard of that.

    If these immunotherapies succeed even partially in slowing down disease progression, in many cases, probably running into tens of thousands, recourse to life-changing radical treatment could be avoided.

    Best wishes.

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