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What Dietary Supplements Can Be Used for Prostate Cancer?

In recent years, there has been a trend toward complementing or replacing treatment options with dietary supplements. Dietary supplements, also referred to as nutraceuticals, are substances that contain specific nutrients, including vitamins, minerals, and plant extracts, among other ingredients, that are used for medicinal purposes.1 While some nutraceuticals may help improve health or support important bodily functions, there is little evidence on their ability to significantly impact, or cure, chronic conditions. In regard to prostate cancer specifically, no direct link between any vitamin, mineral, or plant extract supplement has been found to decrease the risk of developing prostate cancer or slow down the cancer’s progression.2-5

Very few large, controlled studies have been performed on dietary supplements and their effect on prostate cancer, which is a major contributing factor to lack of evidence on the issue. Of the studies that do exist, many are small and have results that are contradicting of one another. The rise in popularity of nutraceuticals has increased the desire and need to know more about these kinds of supplements, and a growing number of larger, controlled trials are in the works. Hopefully, these will lead to further information, but for now, the link remains unclear. Nonetheless, many individuals still utilize nutraceuticals in hopes that they may be beneficial to their prostate cancer. If you do choose to utilize supplements during your prostate cancer battle, it is very important to discuss with your doctor first, since not all supplements are what they are advertised to be, and some can decrease the effect of prostate cancer medications or treatments.

Some common dietary supplements used by individuals with prostate cancer are:


Antioxidants are naturally occurring in many healthy foods like fruits and vegetables, and protect our body against free radicals, also called oxidants. Oxidants are naturally produced by our body to fight off bacteria and viruses, however, when our body is making too much of these, or is exposed to additional oxidants from cigarette smoke, alcohol, air pollution, and other environmental sources, they can cause damage to our cells. No definitive evidence has been found that links antioxidants to decreasing the risk of developing prostate cancer or slowing its progression.2-6 Several examples of antioxidants taken by individuals with prostate cancer include:

  • Lycopene: Healthy prostates typically have high concentrations of lycopene. Lycopene can be found in tomatoes, grapefruit, and watermelon. Small studies have indicated that lycopene may reduce the risk of developing aggressive prostate cancer or slow the progression of the cancer when taken in high dosages, but no concrete link has been found.2,7,8
  • Vitamin A: Involved in healthy immune function, vision, reproduction, and cell growth. Conflicting evidence has been reported as to whether or not Vitamin A could reduce the risk of developing prostate cancer.3-5
  • Vitamin E and Selenium: Vitamin E helps plays a role in neurological functioning and gene expression in addition to many other roles. Selenium is a trace element that helps certain enzymes in our body function. Selenium is naturally found in nuts, fish, meat, and mushrooms. Few small trials have suggested that these could reduce prostate cancer risk, however, when investigated further, controlled Selenium and Vitamin E Cancer Prevention Trial (SELECT Trial), these were found to be associated with no change in risk of developing prostate cancer, with some individuals taking these actually increasing their risk of developing prostate cancer, so the trial was ended early.2-4,9
  • Polyphenols (flavonoids): Polyphenols are synthesized by vegetables, fruits, and other plants that are thought to have anti-inflammatory and anti-cancer properties. Flavonoids make up the largest family of polyphenols. Examples of sources of polyphenols are berries, tea, pomegranate juice, lettuce, and spinach. Most studies have found a very minimal, if any, association with polyphenols and prostate cancer.2-5,10

Other vitamins and minerals

Several other vitamins and minerals that are not thought to be antioxidants have been studied, and have also been found to have no definitive beneficial connection to prostate cancer. One example of these, calcium, has even been associated with an increased risk of developing prostate cancer.2-5,11 On the other hand, some medications used to treat advanced prostate cancer that has metastasized to the bones may require you to take calcium and vitamin D supplements. Examples of these other vitamins and minerals include:

  • Vitamin D
  • Vitamin C
  • Calcium
  • Zinc

Herbal extracts

Similar to all of the other supplements there is no definitive link between herbal extracts and prostate cancer. Some herbal extracts, like St. John’s wort, interacts with many medications and can actually decrease the effectiveness of some cancer drugs. Other plant extracts, like saw palmetto, may help treat benign prostatic hyperplasia (BPH), which is the non-cancerous growth of the prostate gland during the aging process, however, no strong evidence has shown that saw palmetto decreases the risk of prostate cancer or helps prevent prostate cancer.2,12,13

Important things to note about dietary supplements

There are still many benefits of taking dietary supplements in general to keep your body healthy and functioning. However, having too much of certain vitamins or minerals can be dangerous, interact with, or reduce the effectiveness of treatments you’re on, so it’s important to talk with your doctor about any supplement you are considering trying. Also, there is no FDA regulation process for supplements, which can lead to misleading information. For example, it could be possible that the active ingredient you’re looking to take may not even be in the supplement, or may vary significantly from the advertised dosage. Also, since there is no regulation process, some supplements can contain other ingredients than what is advertised, including hormones or toxins.

Written by: Casey Hribar | Last reviewed: July 2019
  1. Nasri H, Baradaran A, Hedayatollah S, Rafieian-Kopaei. New concepts in nutraceuticals as alternative for pharmaceuticals. Int J Prev Med. Dec 2014; 5(12), 1487-1499. Available from: Accessed October 5, 2017.
  2. Eylert MF, Persad R. Complementary therapies in prostate cancer. Trends in Urology and Men’s Health. May 2011; 2(3), 17-22.
  3. Yacoubian A, Dargham RA, Khauli RB, Bachir BG. Overview of dietary supplements in prostate cancer. Curr Urol Rep. Nov 2016; 17(11), 78.
  4. Marra G, Oderda M, Gontero P. Dietary supplements and prostate cancer prevention. Trends in Urology and Men’s Health. 26 Jan 2016; 7(1), 12-16.
  5. Posadzki P, Soo Lee M, et al. Dietary supplements and prostate cancer: A systematic review of double-blind, placebo-controlled randomized clinical trials. Maturitas. 1 Jun 2013; 75(2), 125-130.
  6. Antioxidants. Medline Plus. Accessed October 1, 2017.
  7. Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective. World Cancer Research Fund and the American Institute for Cancer Research. Published 2007. Accessed October 1, 2017.
  8. Etminan M, Takkouche B, Caamaño-Isorna F. The role of tomato products and lycopene in the prevention of prostate cancer: A meta-analysis of observational studies. Cancer Epidemiol Biomarkers Prev. Mar 2004; 13(3), 340-5. Available from: Accessed October 1, 2017.
  9. Lippman SM, Klein EA, et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. Jan 2009; 301(1), 39-51. Available from: Accessed October 1, 2017.
  10. Clark K. Polyphenols vs. Flavonoids. Published October 3, 2017. Accessed October 5, 2017.
  11. Zinc and Prostate Cancer. Harvard Health Publishing: Harvard Men’s Health Watch. Published March, 2006. Accessed October 5, 2017.
  12. Complementary and Alternative Medicine. National Institute of Health: National Cancer Institute.
  13. Bonnar-Pizzorno RM, Littman AJ, Kestin M, White E. Saw palmetto supplement use and prostate cancer risk. Nutr Cancer. 2006; 55(1) 21-7.