What Is Flutamide (Eulexin)?

Overview

Eulexin (flutamide) is an androgen receptor inhibitor, also called an antiandrogen or a nonsteroidal antiandrogen (NSAA), that is used in combination with other hormone therapies called LHRH agonists (also called GnRH agonists). It is indicated for use in individuals with advanced prostate cancer that has metastasized to other parts of the body. Eulexin is an orally administered medication that comes in capsule form. Individuals taking Eulexin should also be monitored for changes in liver functioning as well as any other liver conditions.

What are the ingredients in Eulexin?

The active ingredient in Eulexin is flutamide, the nonsteroidal antiandrogen.

How does Eulexin work?

Eulexin’s active ingredient binds to the androgen receptor in the body. Eulexin blocks testosterone and other androgens from activating these receptors. Prostate cancer tumors are often fueled to grow by androgens, including testosterone. Turning off the body’s ability to respond to testosterone can potentially halt tumor growth. In addition, Eulexin can be used during early stages of other hormone therapies, such as treatment with Gonadotropin-Releasing Hormone (GnRH) agonists, in order to block the initial surge of testosterone, called tumor flare, that can come along with these medications. The surge of testosterone at the beginning of some of these treatment methods can contribute to rapid tumor growth before it is halted, potentially leading to life-threatening issues such as spinal cord compression.

What are the possible side effects of Eulexin?

Multiple clinical trials evaluated the safety and efficacy of Eulexin. The most common side effects of Eulexin include hot flashes, swelling or pain of the breasts, decreased libido, impotence, diarrhea, nausea, and vomiting. This is not an exhaustive list of all potential side effects of Eulexin. Talk to your healthcare provider or pharmacist for further information.

Things to note about Eulexin

Several rare but more serious side effects can accompany Eulexin including problems with your liver. Individuals should be closely monitored for signs of these serious side effects, and blood tests to assess liver function should be performed regularly. Alert your provider immediately if you notice any of the following symptoms:

  • Nausea and vomiting
  • Stomach or abdominal pain
  • Flu-like symptoms like soreness or muscle aches
  • Fatigue
  • Brown urine
  • Yellowing of the skin or whites of eyes (jaundice)
  • Loss of appetite
  • Inability to urinate

You should also contact your provider if you notice any signs of an allergic reaction to the medication, including chest pain or difficulty breathing. It is also important to consult the prescribing information for any other medications taken with Eulexin, including any LHRH agonists.

Before staring Eulexin talk to your provider if you:

  • Have any liver problems
  • Have any other medical conditions
  • Are currently taking any other medications, vitamins, or herbal supplements

You should not take aspirin or aspirin-containing products unless your doctor specifically indicates that you can. You should also contact your provider if you notice any signs of an allergic reaction to the medication, including chest pain or difficulty breathing.

Dosing information

Eulexin is administered orally and is commonly taken with a LHRH (or GnRH) agonist. Typically, Eulexin is taken three times a day at evenly spaced intervals. Your provider will determine the appropriate dosage and administration schedule for you, as well as the appropriate dosage and administration of any other medications taken with Eulexin. A typical dosage and schedule for Eulexin is 250 mg every 8 hours. It is important to follow this schedule exactly as instructed, and not to stop taking Eulexin or any accompanying medications on your own. If you miss a dose of Eulexin, take your next dose at the regularly scheduled time, and do not try to make up for missed dosages. Eulexin capsules can be opened and mixed in with applesauce or other soft foods. It is important to cut back on or avoid alcohol and drink plenty of water while taking Eulexin.1

Written by: Casey Hribar | Last reviewed: October 2017
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