What Is Cabazitexel (Jevtana)?
Jevtana (cabazitaxel) is a chemotherapy treatment option that has antineoplastic properties (meaning that it acts to prevent or halt the development and growth of tumors). It is indicated for use with prednisone in individuals with metastatic hormone refractory prostate cancer (prostate cancer that has spread to other parts of the body and does not respond to hormone therapy) who have previously been treated with a docetaxel treatment. Jevtana is administered intravenously (IV injection into a vein) and is typically administered over a 1-hour period once every 3 weeks. Jevtana is considered a second-line therapy. In some cases, Jevtana may be used with other hormone therapies. Individuals taking Jevtana should also be monitored for changes in blood cell counts, serious infections or allergic reactions, severe diarrhea, and changes in liver or kidney functioning.1
What are the ingredients in Jevtana?
The active ingredient in Jevtana is cabazitaxel, the chemotherapeutic agent.
How does Jevtana work?
Jevtana’s active ingredient has antineoplastic properties, meaning that it acts to prevent tumor growth and development. Jevtana does this by binding to the microtubules in a cell which play a key role in allowing cells to physically divide during the replication process. When a parent cell is unable to split into two daughter cells, it will eventually become too faulty and will die. When a cell manually kills itself because of a faulty cellular process it is called apoptosis. Chemotherapies cause cancer cells to stop dividing and undergo apoptosis, thus, slowing or halting the growth of a cancerous mass.
Cancerous cells are rapidly dividing while most other cells in our body aren’t, or are doing so at a slower rate. This property is what increases the chances of chemotherapies targeting cancer cells. However, there are still a few kinds of cells in our body that divide rapidly, such as hair cells or cells that line our intestines, which explains the common side effects of hair loss or gastrointestinal disruption while on a chemotherapy medication. Blood cells, including important white blood cells, red blood cells, and platelets also divide on a regular basis, making it important to closely monitor someone on chemotherapy for to make sure their blood cell counts aren’t dangerously low. If a person’s blood cell count dips below a certain threshold, they will be unable to receive chemotherapy until the issue has resolved.
Additionally, steroids like prednisone are typically used with chemotherapies to increase their effectiveness when it comes to targeting and killing cancer cells as well as to prevent life-threatening swelling and other side effects.2
What are the possible side effects of Jevtana?
Multiple clinical trials evaluated the safety and efficacy of Jevtana across many different conditions. The most common side effects of Jevtana include feeling short of breath, decreased appetite, fatigue, changes in your sense of taste, constipation, nausea, vomiting, joint or muscle pain, diarrhea, hair loss, rash, skin reactions at the injection site, and back pain. Many of these symptoms, including hair loss, are generally reversible and will be remedied when the medication is stopped. Your provider will be able to determine what symptoms may be longer-lasting in nature. This is not an exhaustive list of all potential side effects of Jevtana. Talk to your healthcare provider or pharmacist for further information.
Things to note about Jevtana
Several rare but more serious side effects can accompany Jevtana including neurological symptoms, changes in liver function, and serious gastrointestinal symptoms. Alert your provider immediately if you notice any of the following symptoms:
- Numbness, tingling, or burning of hands or feet
- Muscle aches
- Blood in your urine
- Burning when urinating
- Yellowing of the skin/eyes
Severe gastrointestinal symptoms such as extreme vomiting or diarrhea can deplete your body’s electrolytes and fluid supply. If these symptoms become too severe, they can deplete your body fluid and lead to death. This can also cause kidney failure if your body is under extreme dehydration. Alert your provider immediately if you have any of the following symptoms:
- Severe diarrhea
- Severe vomiting
- Swelling of your face or body
- A decrease in the amount of urine produced daily
Additionally, there is a risk of developing very low white and red blood cell and platelet counts while taking Jevtana. Your doctor will monitor you for any signs of this, however, it is important to self monitor for any signs of infection, shortness of breath, fatigue, unusual bruising, or bleeding. Individuals with a white blood cell count that is deemed to be too low to be able to handle the continuation of treatment will need to stop taking Jevtana until their blood cell count rises.
Before staring Jevtana talk to your provider if you:
- Have any problems with your liver or kidneys
- Are over the age of 65
- Are allergic to Jevtana or any of its ingredients, or have any other allergies
- Have a low white blood cell count, red blood cell count, or platelet count
- Have any other medical conditions
- Are currently taking any other medications, vitamins, or herbal supplements
You should also contact your provider if you notice any signs of an allergic reaction to the medication, including chest pain or difficulty breathing. Jevtana contains alcohol in an amount that may potentially impair your ability to drive or operate any machinery. It is important to limit any of these activities post-treatment until safe to continue. It is also important to consult the prescribing information for any other medications taken with Jevtana, including prednisone.
Jevtana is administered intravenously (IV), meaning through an injection into a vein. A typical injection of Jevtana takes about an hour to administer, and is given once every 3 weeks. There is also a premedication regimen that contains an antihistamine, corticosteroid, and other medications that is typically provided intravenously 30 minutes prior to administering Jevtana that may help prevent any injection site or allergic reactions. Your provider will determine if this is necessary for you, as well as the appropriate dosage and administration schedule for you, including your length of treatment. They will also determine the appropriate dosage and administration schedule of any other medications taken with Jevtana, such as prednisone.
It is important to follow your provided schedule exactly as instructed, and not to stop taking any accompanying medications on your own. The dose of your Jevtana can be adjusted as needed, and may need to be discontinued if your blood cell count is too low or if the side effects of treatment become too severe.1
- Jevtana Prescribing Information. FDA.gov. June 2010. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/201023lbl.pdf.
- How Chemotherapy Works. Cancer Research UK. http://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/chemotherapy/how-chemotherapy-works. Published December 13, 2014. Accessed September 1, 2017.