What is Nubeqa® (darolutamide)?

Nubeqa® (darolutamide) is used for the treatment of prostate cancer that has not spread to other parts of the body and no longer responds to testosterone-lowering treatments. This type of cancer is called non-metastatic castration-resistant prostate cancer (nmCRPC).1

Darolutamide is an androgen receptor inhibitor used to block the signal of the androgen receptor for those with prostate cancer.1

How does darolutamide work?

The hormones in your body carry messages through your bloodstream to your tissues or organs. They affect many complex processes within your body, including:2

  • Mood
  • Sexual function
  • Reproduction
  • Growth and development
  • Energy use from food

Androgens are a family of hormones that include testosterone. Testosterone plays a major role in male development and health. The development and growth of prostate cancer is complex, and the exact process is still not entirely known. However, an abnormal signaling of the androgen receptor may be a factor in the development of prostate cancer.3,4

Some men have a type of prostate cancer that needs to be treated by lowering testosterone levels. If the cancer comes back, the androgen hormone in your body may be low but the signaling of the receptor in your body may still be abnormal. When this treatment is used and the cancer grows back, an androgen receptor inhibitor drug may be prescribed.4,5

Darolutamide is an androgen receptor inhibitor drug that blocks the signal of the androgen receptor. This treatment may be effective in treating this type of prostate cancer.1

What are the possible side effects of darolutamide?

The most common side effects of darolutamide include:6

  • Feeling more tired than normal
  • Arm, leg, hand, or foot pain
  • Rash
  • Decreased blood cells that help fight infection
  • Changes in liver function

These are not all the possible side effects of darolutamide. Talk to your doctor about what to expect or if you experience any changes that worry you.

Things to know about darolutamide

If you have severe kidney or liver disease, darolutamide may build up in your body at an unsafe level. Talk to your doctor about your medical history to make sure the correct dose is given to you.6

There is not enough information about darolutamide to know if this drug is safe for women. Darolutamide may be harmful to a developing baby can cause loss of pregnancy. Effective birth control should be used if your female partner is of childbearing age. darolutamide may interfere with a male’s ability to reproduce.6

Tell your doctor about any other drugs, vitamins, or supplements you are taking. This includes over-the-counter drugs.

For more information, read the full prescribing information of darolutamide.

These are not all the possible side effects of darolutamide. Patients should talk to their doctor about what to expect with treatment with darolutamide.

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Last reviewed: August 2020