My dad had a psa level of 2.1 last year and this year it is 154. His prostate cancer has moved to bones but thankfully no organs. There is a spot on ureter tube . He started hormone therapy (2 meds) a couple months ago and psa is down to 72 as of a month ago. Chemo was an option given but after meeting about it we decided against it because he would be giving up quality of life. We are hoping to go to md Anderson in September for a second opinion but trying to find people who have rare, aggressive and advanced prostate cancer to talk to.