I have been reading this forum for a while and have to say that y'all give me hope no matter how my personal situation turns out in the end. I'll give a brief synopsis of where I am at as a 64-year old patient.
So far I've had 6 (yes, I said six) negative prostate biopsies over the past 20 years. My PSA was 10 for years and just went up to 14 late last year. My last 2 biopsies (last year and this year) were mpMRI targeting a lesion and including transitional zones with 14 cores taken each time and all were negative showing typical BPH cells. My prostate size is > 2x the norm which could account for some of the elevated PSA numbers.
Next steps from the docs are monitor the PSA and if it continues to rise do a saturation biopsy next. At some point they will either find a PCa or just chalk it up to BPH. The waiting and uncertainty is the worst part of the whole thing. Still, I have what are considered the best urologists in Atlanta, so feel good about their expertise.
Bottom line is I'm not overly stressing, but hope that others in a similar position can share their experiences. It is a strange place to be.