My Dads Advanced Prostate Cancer
Hi new here happy to have found an informed and helpful community in relation to this terrible disease. My Dad (82) has today unfortunately been asked to make a decision on his next course of treatment for his apc. To date he has tried zoladex, radiation therapy, and most recently abiraterone. His choice now is to choose between chemo - doccetaxal every 21 days in conjunction with Prednisolone or to potentially take part in a clinical trial of either just 160mg of enzulatamide or group b enzulatamide 160mg plus Lu-PSMA. I believe it might be customary to try enzulatamide if arbiraterone is not working so I’d suspect he’d be better to try that before chemo? If that is at least possibly true should he participate in the trial with the 50% chance of simultaneously trying Lu-PSMA? Is much known about the latter. don’t want him to be a guinea pig near the end of his life. Any informed assistance in making this decision would be greatly appreciated. Need to confirm with his oncologist in 4 days time!
Hi
. So sorry to hear about your father's situation. I can't speak personally to the treatment, but I did find this study In the Lancet which compared Lu-PSMA-617 to cabazitaxel and found it favorable and concluded that it "is a new effective class of therapy and a potential alternative to cabazitaxel:" https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00237-3/fulltext. In addition, this article from only four days ago details its success in a phase III trial: https://www.nejm.org/doi/full/10.1056/NEJMoa2107322. I hope this information is helpful and wishing you and your father the best. Richard (ProstateCancer.net Team) Thank you for your kind response and informed input Richard, it is greatly appreciated.
would you mind sharing what choice you made and the outcome please? 
Clinical trials are often misunderstood. If the new drug is not working the trial will stop. If it is working you most likely will be either A) given the new medication during the trial or B) you will have access to it earlier than those who have not participated in the trial. During a trial they keep a very close eye on you and your reactions - you are not left unattended or left to suffer with a placebo. Personally I feel it is a good idea to explore all options offered when they make sense
