What is Prostate Cancer?

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Prostate cancer, like all cancers, is the unregulated growth of cells in the body. For men with prostate cancer, this non-stop growth of cells creates masses, or tumors, in the prostate gland. Prostate cancer is the second-leading cancer among men in the U.S., next to skin cancer.

The prostate gland is part of the male reproductive system and makes a clear to white-colored fluid that mixes with sperm produced in the testes to eventually become semen. The prostate is located below the bladder and behind the pubic bone near the base of the penis and sits in front of the rectum.

The figure below illustrates the location of the prostate gland (shown in blue) as well as the areas where the cancer from the prostate may grow. The primary tumor may grow through the wall of the prostate and spread to nearby organs identified in the diagram, or metastisize to lymph nodes or bones.

Figure 1. Location of prostate gland and potential areas of tumor growth

As of 2014, there are over 3 million men living with prostate cancer in the United States alone.1 The majority of prostate cancer cases are classified as being “localized” to the prostate, and nearly all cases are considered adenocarcinomas, meaning the cancer develops in the cells lining the gland. Prostate cancer is the most common cancer in American men, after skin cancer.2

Who gets prostate cancer?

Since only males have a prostate gland, prostate cancer is a sex-specific cancer. Prostate cancer typically affects males later in life, with the median age of diagnosis being 66 years old. Although it is more uncommon to be diagnosed with prostate cancer at a young age, this does occasionally happen. Roughly 9.3% of prostate cancer cases are diagnosed in men between the ages of 45-54, and 32.8% are diagnosed between the ages of 55-64, however, the largest proportion of diagnoses occurs in individuals between 65 and 74 years old.

African American men have the highest incidence rate of prostate cancer, and the condition typically affects non-Hispanic men more than Hispanic men. Improvements in screening methods, such as new imaging techniques and the use of the prostate-specific antigen (PSA) test, have allowed for earlier detection of prostate cancer, which is why most cases are found early on.1-3

Symptoms and detection of prostate cancer

Depending on your age and family history of prostate cancer, your doctor will determine when it is appropriate for you to start receiving prostate cancer screenings. Very early prostate cancer rarely shows symptoms, and is often suspected after abnormal PSA tests or digital rectal exams (DREs). When an abnormal result is found during a routine screening, further diagnostic testing may be completed, such as biopsies to further classify suspicious cells, or images like MRIs. Prostate cancer does eventually start showing symptoms, with the most common being:

Once a prostate cancer diagnosis has been suspected or confirmed, your provider will help you choose the most appropriate treatment method for your situation.

Causes of prostate cancer

Prostate cancer is caused by uncontrolled cell growth leading to the development of tumors. The exact mechanism responsible for prostate cancer is unknown, and could be due to multiple issues or mutations present in an individual’s genes or cells. Normally, cells divide at an appropriate pace, and perform “damage checks” to make sure that newly formed cells are healthy. When cancerous mutations are present, these checks do not happen, and tumors are formed when unhealthy cells are allowed to keep growing and dividing. This is the cause of cancers like prostate cancer.

There are also risk factors for prostate cancer, which aren’t causes of the condition, but rather are factors that could create the gene mutations that ultimately lead to cancer. Risk factors for prostate cancer include advanced age, race, and family history. Possible risk factors include environmental exposure to cancer-causing agents such as cigarette smoke and Agent Orange, and obesity, among others.3-5

Prostate cancer prognosis and treatment

The good news for individuals with prostate cancer is that the condition is typically caught early on, thanks to advances in screening techniques and imaging capabilities. The five-year survival rate for local and regional prostate cancer (roughly stages I-III and potentially IV if the cancer hasn’t spread too far beyond the prostate) is nearly 100%. Estimates for the 10-year and 15-year survival rates of individuals in this group are also high, and are both estimated to be above 90%. These statistics decrease for those who are diagnosed with very advanced or distant prostate cancer that has spread to far away lymph nodes, bones, and other organs. Individuals in this category have a five-year survival rate of roughly 29%. As of 2014, the death rate for prostate cancer-related mortality has reached its lowest, at of 19.1 deaths per every 100,000 men of all demographics in the United States.6,7

There are many treatment options for prostate cancer, including radiation, surgery, chemotherapy, and hormone therapy, among others. Treatment decisions will be based on the stage and grade of the cancer, an individual’s age and expected lifespan, other medical conditions that are present, potential side effects, and an individual’s desire to treat. In many instances, when the cancer is caught early and is suspected to be non-aggressive, active surveillance or watchful waiting of the cancer may be an option as opposed to intense treatment options with potential side effects. Your provider will work with you to determine what options are best for you, and the most applicable to your situation.

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view references
  1. SEER Cancer Stat Facts: Prostate cancer. National Cancer Institute. https://seer.cancer.gov/statfacts/html/prost.html. Published April 2017. Accessed August 10, 2017.
  2. Key Statistics for Prostate Cancer. American Cancer Society. https://www.cancer.org/cancer/prostate-cancer/about/key-statistics.html. Published January 5, 2017. Accessed August 10, 2017.
  3. Attard G, Parker C, Eeles RA, et al. Prostate cancer. The Lancet. Jan 2016; 387(10013), 70-82. http://www.sciencedirect.com/science/article/pii/S0140673614619474?via%3Dihub Accessed August 10, 2017.
  4. NCCN Guidelines for Patients: Prostate cancer. National Comprehensive Cancer Network. Version 1.2016. Accessed August 10, 2017 at: https://www.nccn.org/patients/guidelines/prostate/index.html
  5. Prostate Cancer Risk Factors. American Cancer Society. https://www.cancer.org/cancer/prostate-cancer/causes-risks-prevention/risk-factors.html. Published March, 11, 2016. Accessed August 10, 2017.
  6. Skolarus TA, Wolf AM, Erb NL, et al. American Cancer Society prostate cancer survivorship care guidelines. CA Cancer J Clin. 2014;64:225-249.
  7. Survival Rates for Prostate Cancer. American Cancer Society. https://www.cancer.org/cancer/prostate-cancer/detection-diagnosis-staging/survival-rates.html. Published May 30, 2017. Accessed August 10, 2017.
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Written by: Casey Hribar | Last reviewed: October 2017
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