3 + 4

Hi Deanne. I too was diagnosed as 3+4, and my Urologist explained that if there was good news, it was that he thought we had time to run additional tests to understand the exact nature of my cancer before deciding on a treatment. After genetic screening, 2 MRIs, full-body bone scan, 2 more MRIs and a final PSA, all the doctors and radiologists didn't think the cancer had spread.

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My results are not at all typical but I had a Gleason score of 3+4, 4+3 (two positive samples) and I was already stage 4. My PSA was 7.2 so the fact that it had spread was unexpected. After the biopsy I had an MRI and that's when it was discovered that it had spread outside of the prostate and that I had metastases to bone. Again, not at all typical but possible. For me the MRI was the only indication that this was not a 'normal' prostate cancer.

Hi . I can't personally speak to this question, but I found this research article that may be helpful: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907332/. It is actually comparing incidence of metastasis between Gleason 3+4 and 4+3, but in the process gives stats on both. In this study the incidence of metastasis for the 3+4 group was 0.9% or 9 out of 1041 - so, pretty rare. Wishing you the best. Richard (ProstateCancer.net Team)

The psma pet scan results came back this morning. One of the comments are 'Focal mild PSMA uptake with the T10 vertebral body, with no CT correlate, is indeterminate. A small/early bony metastatic deposit is a possibility.'
My husband is having another MRI on this area next week. No evidence in the lymph nodes.
Wondering what the thoughts on this is?


Thanks