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ExoDx liquid biopsy and physical biopsy

Hi all,
I'm 67 years old, active and otherwise healthy at this point. I had a liquid biopsy (Exo Dx) a few weeks back and the results were a little scary. Scale is 15.6 which appears to be the watchful waiting threshold and above that indicates possibility of aggressive cancers. My score was 70, Doc says he's never seen a number that high... While I know this is not diagnostic of cancer it does run in my family. Both my father's brothers have had prostate cancer and my dad died at 52 of melanoma. My PSA scores have been steadily rising for about four years and to complicate matters my genetic testing shows I have Lynch Syndrome which predisposes you to certain cancers. I have already had a colectomy in 2019 for colon cancer (got it all early, no chemo or radiation). Scheduled for Prostate Biopsy at 2:00 today. Anyway, not sure why I'm putting this out here other than to unload a bit without freaking out my wife. Thanks for being out there. Now for the waiting part.....I'll check in later.

  1. Just back from biopsy. Not too bad. Sore and just chilling. Results in 7-10 days. Doc says from the other Exo Dx results I have 50/50 chance of having an aggressive cancer..

    1. The waiting is always the worst part. Hang in there and know you are not alone - many supportive readers here. And if you are comfortable in sharing please keep us updated. Wishing you the best.

      1. Thanks.

        1. Doc called with results yesterday. 11 of the 12 samples were fine. The 12th indicated cancer in the "watch and monitor stage". Have my follow-up appt on the 28th to see what game plan will be proposed. Still concerned because of Lynch Syndrome's effects on certain cancers but will discuss this then too. Feeling pretty relieved today. Thanks for the chance to talk...

          1. Hi . Did the doctor also report the Gleason score to you? That will go a long way towards dictating options for next steps. Your concerns about the increased cancer risk related to Lynch Syndrome are certainly understandable. I do want to share with you this article that notes that, while there is an increased risk of prostate cancer it does "not appear to have earlier onset or a more aggressive phenotype:" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289599/#:~:text=Males%20with%20Lynch%20syndrome%20had,or%20a%20more%20aggressive%20phenotype. Wishing you the best and please feel free to keep us posted on how things are going. Best, Richard (ProstateCancer.net Team)

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