Have been taking Lupron for years off and on. Do remember lack of energy and aches and pains, and of course hot flashes. But other than that-it was not terrible for me and it did slow the cancer down. I know its hard-but exercise will help-even if its a drain to do it. Would definitely talk to your doctor-maybe intermittent dosage of a different course for you. Feel you and wish you the best. Please keep in touch. DanF, moderator, prosttecancer.net.