Hi . I can't personally speak on this issue, but I do know that several of our contributors have noted that their Lupron side effects lasted quite a while after the last shot and beyond what was expected. Unfortunately, research also supports the effects potentially lasting a while. This research found 80% of participants reporting side effects lasting more than 6 months after stopping treatment: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997553/#:~:text=Almost%20all%20(96%25)%20reported,%2C%20insomnia%2C%20and%20hot%20flashes. The good news is that in-spite of the long-term effects two-thirds of respondents said they would still recommend the treatment to others. Hoping you feel some relief soon. Best, Richard (ProstateCancer.net Team)