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Odd Reaction to Third Lupron Shot

I had my third monthly Lupron shot two days ago and woke up this morning feeling amazingly energized and also beyond ecstatically happy, literally the way I felt for the 15 seconds before going under when given propofol before my biopsy only I've been feeling that way all day long, about nine hours now. It's almost frightening because I've been insanely productive today--did some work, went to the gym, walked the dog for 90 minutes, and now heading out to clean the house.

I know Lupron has made me feel like I'm in a pit of depression but this is literally the exact opposite. Is this a possible side effect? I'm kind of waiting for the other shoe to drop and wondering if I should let my care team know, but then again it's great to feel this way for the first time in a long time so maybe just go with it?

  1. Hi that is great! I am so glad to hear that you are feeling energized and have been super productive. I can also understand why you would be questioning this euphoric state, considering how you have been feeling for so long. I reviewed past forums and stories and couldn't find any information about this being a side effect of lupron. I am hoping this is you getting your energy back and making you feel mentally and physically great. Please keep us posted and I really hope this continues for you. I would mention this to your doctors as it is always good to keep them informed, and it is good to share great news. Jill, prostatecancer.net team

    1. Thanks Jill. All I could find was one article about a case of Lupron-induced "mania" but I definitely wasn't out of my mind. Then again, my side effects from Lupron seem to be very different than most other people. I haven't had any hot flashes at all, but instead get chills once or twice a day where going outside on a hot day feels good instead of uncomfortable. I've been seeing a therapist for a month now so that may be helping as well.

      1. I hope it is all of the things you are doing- seeing a therapist, exercising, giving your body time, etc. I really hope you continue to feel well. Jill, prostatecancer.net team

    2. Hi Njguy,

      I am happy that you are feeling well but I've never read what you have described as something that happens with Lupron or any other hormone blockers.

      Depression, brain fog, fatigue, hot flushes, ... those are the undesired but expected side-effects from Lupron (and from being Testosterone deprived. Even had you skipped your injection, you would not have felt any improvement for probably a few more weeks because Lupron takes a long time to fully exit your system.

      The only thing I can think of is that you might have done something else that does not have to do with Lupron, maybe a few days earlier, and that happened to kick in roughly at the time of your injection. A new anti-depressant? Trying Ritalin for the first time?

      Or.... Is it possible that there was a mix-up and they ended up injecting you with something other than Lupron?


      1. Thanks. Unfortunately, I think it was just a really good day and I hadn't one in such a long time that it felt unusual. As I said in my post, though, I've been getting chills from ADT instead of hot flushes but the doctor told me that's just what happens to some people.

    3. I just asked an AI: "Are there any cases where, after getting a Lupron injection, someone woke up feeling amazingly energized and also ecstatically happy?".

      It could not mention any.

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