Post-TULSA ablation genomic testing of biopsy material??
Gents, I have a TULSA Pro ablated prostate (approx 13cc size) from 2.5 yrs ago. Looking for genomic testing recommendation of biopsy material. Dr. told me that the Decipher genomic test won't perform given the ablation. There are other genomic test methods out there such as Foundation One (liquid), Oncotype DX, Prosta Vision, Prolaris, etc. Does anyone know if any of these genomic tests would be accurate on post-ablation biopsy material?
A bud of mine needed to undergo a TURP and asked his urologist what the differences were between a surgical procedure and laser. He was told that the latter process destroyed the material to a point where any follow up testing was not physically possible.
He chose surgery at the time and was grateful he did. That was 5 years ago and I am not familiar if there is newer testing procedures available today that can use ablation material. Perhaps someone here may have some knowledge of any new developments. May I ask what is behind your question? Are you currently experiencing a rise in PSA etc or ??? Dennis(ProstateCancer.net TEAM)Dennis, "yes" I'm experiencing a slight rise in PSA but still <10. I'm trying to understand whether I'm dealing with a "lion" or a "lamb" to enable me to make a more informed decision regarding next steps. Recent MRIs, CT and other diagnostics all look relatively "clean". Of the 20 saturation biopsy cores I had 3 from the left lobe (or what remains of it) that had a 3+3=6. So, I'd like to have those 3+3s genomically assessed (i.e. aggressive or not).
Hi
. Just to follow up on what Dennis said, this article Memorial Sloan Kettering notes that "During a prostate ablation procedure, energy (such as heat, cold, lasers, or chemicals) is used to kill the cancer cells. The energy may also destroy some of the surrounding normal prostate tissue:" https://www.mskcc.org/cancer-care/patient-education/about-prostate-ablation-procedure#:~:text=Prostate%20ablation%20is%20a%20procedure,the%20surrounding%20normal%20prostate%20tissue. That said, since ablation leaves part of the prostate intact I'm not sure why material taken from this area would be unavailable for genomic testing. Of course, I'm no expert and this is definitely a question for a doctor. I did do some searching and could not find any research noting the ability of any genomic tests to render a result following ablation (and I previously wrote two articles on urinary biomarker tests). This, of course, doesn't mean it doesn't exist. Hoping you can get some answers and please feel free to follow-up with us if you do. Best, Richard (ProstateCancer.net Team)
