- You didn't mention what you were taking but, from the dose, I am guessing it is Orgovyx. I took Orgovyx for 2 months and I did not have any fatigue. I guess it is possible during longer courses of treatment. I did get the annoying hot flashes but that really was no biggie. Based on what I have read, Orgovyx is what I would chose again versus the shots and, in my opinion, it isn't even a close call. Testosterone crashes pretty quickly and, for me, I was aware of the returning testosterone 4 weeks after stopping and it measured in the normal range after 7 weeks.
Personally, I wouldn't mess with weed while dealing with non metastatic PC and, assuming radiation treatments. Tell us a bit more about yourself, diagnosis, and treatment plan.