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Decipher Genomics testing

Has anyone had this test done and if so what kind of results can I expect? My oncologist recommended this test prior to my radiation to see if I will need to go on a hormone in addition to the radiation.

  1. Hi . I can't personally speak to the Decipher test, but I want to share with your this Forum page where it was discussed: https://prostatecancer.net/forums/decipher-prostate-test. This Forum also discusses it, but in relation to active surveillance: https://prostatecancer.net/forums/using-decipher-score-to-decide-as-vs-treatment. In addition, in this story another community member wrote about his experience: https://prostatecancer.net/stories/genetic-testing. Here is one more conversation on the genomic testing (Decipher and Polaris: https://prostatecancer.net/forums/my-pc-moved-from-low-risk-to-intermediate-high-risk. Hope this information is useful and that others chime in with their experiences. Best, Richard (ProstateCancer.net Team)

    1. The results of my decipher test show as .65 on a scale of 1 which identifies me as slightly high risk. I am meeting with the radiologist tomorrow to determine if this means I'll need ADT in addition to the radiation.

      1. If the biopsy shows GL 4+3, both ADT should be considered and a PET scan is advised. A high Decipher dissuades against choosing active surveillance if low volume GL3+4. Some docs will consider longer duration of ADT if Decipher is high.

        1. I am starting ADT this week for 6 months and radiation therapy in 2 months. The radiologist said that since my PSA is below .5 it is very unlikely the PET scan would be able to detect it. He gave me the option of waiting around until the PSA rose but I chose to do radiation and he said they are 80% sure where it likely returned (prostate bed and margin area after surgery).

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