Well I received this today...Time to make decisions I guess. 56 years old. psa 5.4
Final Diagnosis
View trends
A. LEFT ANTERIOR APEX- 2 CORES, NEEDLE CORE BIOPSY:
Benign prostatic tissue with focal chronic inflammation.
No malignancy identified.
B. LEFT POSTERIOR APEX- 2 CORES, NEEDLE CORE BIOPSY:
Benign prostatic tissue.
No malignancy identified.
C. LEFT ANTERIOR BASE- 2 CORES, NEEDLE CORE BIOPSY:
Benign prostatic tissue with focal chronic inflammation.
No malignancy identified.
D. LEFT POSTERIOR BASE- 2 CORES, NEEDLE CORE BIOPSY:
Benign prostatic tissue with focal atrophy.
No malignancy identified.
See Comment.
E. RIGHT ANTERIOR APEX- 2 CORES, NEEDLE CORE BIOPSY:
Acinar adenocarcinoma, Gleason 3+4=7 (Grade Group 2), in 1 of 2 cores, involving 15% of the combined core lengths.
Percentage of Gleason pattern 4: 10%.
See Comment.
F. ROI, RIGHT POSTERIOR APEX- 3 CORES, NEEDLE CORE BIOPSY:
Acinar adenocarcinoma, Gleason 3+4=7 (Grade Group 2), in 3 of 3 cores, involving 70% of the combined core lengths.
Percentage of Gleason pattern 4: 10%.
Perineural invasion is present.
See Comment.
G. RIGHT ANTERIOR BASE 2 CORES, NEEDLE CORE BIOPSY:
Benign prostatic tissue.
No malignancy identified.
H. RIGHT POSTERIOR BASE- 2 CORES, NEEDLE CORE BIOPSY:
Acinar adenocarcinoma, Gleason 3+4=7 (Grade Group 2), in 1 of 2 cores, involving 2% of the combined core lengths.
Percentage of Gleason pattern 4: 10%.
See Comment.
Comment
View trends
Following review of the H&E stained slides, it was determined that PIN4 immunohistochemical stains were necessary for diagnosis. The stains support the diagnoses.
Immunohistochemical stains:
Block
Stain
Result
D1-5
PIN-4
Basal cells present; AMACR is not increased; Negative for adenocarcinoma
E1-5
PIN-4
Basal cells absent; AMACR is increased; Positive for adenocarcinoma
F1-5
PIN-4
Basal cells absent; AMACR is increased; Positive for adenocarcinoma
H1-5
PIN-4
Basal cells absent; AMACR is increased; Positive for adenocarcinoma
receiving those biopsy results has to be a lot to take in. I hope you are firstly able to take some time to process everything and have some good, helpful conversations with your doctors about what comes next. I really just wanted to say that I am sending you good thoughts as you navigate these next steps. And also wanted to leave you with some articles that may be helpful to read while you process everything (and that may be helpful when you speak with your doctor): https://prostatecancer.net/diagnosis/gleason-score // https://prostatecancer.net/living/first-treatment-options // https://prostatecancer.net/living/steps-after-diagnosis -Kimberli (Team Member)
