I've been on Orgovyx for about 10 months now. Alone, before chemo, it lowered my PSA from over 40 to around 12. And other than some mood chances, there was not much in the way of side effects. Those came with the chemo and the addition of Xtandi after chemo. Orgovyx appears to be one of the best ADT treatments available. I plan to stay on it long term, along with Xtandi for maintenance.